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KMID : 1134220130330030142
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Hanyang Medical Reviews
2013 Volume.33 No. 3 p.142 ~ p.149
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Experiment of Ischemia/Reperfusion Injury of the Cirrhotic Liver in the Murine Mouse Model
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Kang Koo-Jeong
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Abstract
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As a medical doctor, the final goal of any type of research is focused on better treatment or contemporary care of the patient. As a surgeon, the research is focused on improving results in surgical procedure and improving the immediate to long term outcomes. In human beings, hepatobiliary tract and pancreas (HBP) play a major role in digestion, body metabolism and endocrine function. These organs are sophisticated in pathology as well as anatomy and physiology. The surgery of the hepatobiliary and pancreatic organ is very difficult. Therefore, the hepatobiliary surgeon’s endeavor to treat patients who have hepatobiliary and pancreatic diseases should be scientific and based on evidence in order to get the best result. Here I describe the topic of ischemia/reperfusion injury of the liver from my experience to establish safe surgical resection of the liver with limited bleeding and ischemia/reperfusion injury. Furthermore, I have added ischemia/reperfusion injury in the cirrhotic mouse model, methodology and brief result that I have achieved.
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KEYWORD
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Liver, Reperfusion Injury, Animal Experimentation, Liver Cirrhosis, Apoptosis
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